Epigallocatechin gallate enhances sympathetic heart rate variability and decreases blood pressure in obese subjects: a randomized control trial

Autor:	Kittikorn Tommy Wilasrusmee, Chantacha Sitticharoon, Issarawan Keadkraichaiwat, Pailin Maikaew, Kitchaya Pongwattanapakin, Saimai Chatree, Rungnapa Sririwichitchai, Malika Churintaraphan
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Obesity EGCG HRV MAP Metabolic Hormones Medicine Science
Zdroj:	Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-024-72269-3
Popis:	Abstract This study aimed to investigate effects of epigallocatechin gallate (EGCG) on blood pressure (BP) and autonomic nervous system, indicated by 5-min heart rate variability (HRV) measurement in obese subjects, and determine correlations of BP with metabolic factors. In a double-blind, randomized controlled trial, obese subjects (n = 30) were randomly allocated to receive 150 mg EGCG (n = 15) or placebo (n = 15) twice a day without dietary restrictions. After 8-week EGCG treatment, systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) significantly decreased, while the low-frequency (LF) to high-frequency power (HF) ratio (LF/HF ratio) significantly increased (P
Databáze:	Directory of Open Access Journals
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