Autor: |
Ronald Lautner, Niklas Mattsson, Michael Schöll, Kristin Augutis, Kaj Blennow, Bob Olsson, Henrik Zetterberg |
Jazyk: |
angličtina |
Rok vydání: |
2011 |
Předmět: |
|
Zdroj: |
International Journal of Alzheimer's Disease, Vol 2011 (2011) |
Druh dokumentu: |
article |
ISSN: |
2090-0252 |
DOI: |
10.4061/2011/939426 |
Popis: |
Intensive research over the last decades has provided increasing evidence for neuroinflammation as an integral part in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD). Inflammatory responses in the central nervous system (CNS) are initiated by activated microglia, representing the first line of the innate immune defence of the brain. Therefore, biochemical markers of microglial activation may help us understand the underlying mechanisms of neuroinflammation in AD as well as the double-sided qualities of microglia, namely, neuroprotection and neurotoxicity. In this paper we summarize candidate biomarkers of microglial activation in AD along with a survey of recent neuroimaging techniques. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
|