| Autor: |
Maria Elisa Sabatini, Micaela Compagnoni, Fausto Maffini, Claudia Miccolo, Fabio Pagni, Mariano Lombardi, Virginia Brambilla, Daniela Lepanto, Marta Tagliabue, Mohssen Ansarin, Simona Citro, Susanna Chiocca |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Frontiers in Molecular Biosciences, Vol 9 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2296-889X |
| DOI: |
10.3389/fmolb.2022.940449 |
| Popis: |
Functional loss of E-cadherin is frequent during tumor progression and occurs through a variety of mechanisms, including proteolytic cleavage. E-cadherin downregulation leads to the conversion of a more malignant phenotype promoting Epithelial to Mesenchymal Transition (EMT). The UBC9/SUMO pathway has been also shown to be involved in the regulation of EMT in different cancers. Here we found an increased expression of UBC9 in the progression of Head and Neck Cancer (HNC) and uncovered a role for UBC9/SUMO in hampering the HPV-mediated E-cadherin cleavage in HNC. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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