Features of Cellular and Humoral Immunity Functioning in Patients with Juvenile Rheumatoid Arthritis
| Autor: | H.A. Pavlyshyn, T.A. Kovalchuk, O.R. Boiarchuk, T.V. Hariian |
|---|---|
| Jazyk: | English<br />Ukrainian |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Bolʹ, Sustavy, Pozvonočnik, Vol 5, Iss 4.20, Pp 28-33 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2224-1507 2307-1133 |
| DOI: | 10.22141/2224-1507.4.20.2015.79327 |
| Popis: | The objective was to examine the state of cellular and humoral immunity in children with juvenile rheumatoid arthritis. The study involved 48 patients with juvenile rheumatoid arthritis, 24 patients with reactive arthritis and 22 apparently healthy children. It was found that juvenile rheumatoid arthritis is associated with a likely decrease of CD3+-, CD4+-, CD8+-, CD16+-lymphocytes levels in peripheral blood, high levels of IgA, IgE, TNF-α, IL-4, IL-8 and the unchanged parameters of IgM and IgG, which is associated with chronization of rheumatoid process. The need for close monitoring and long-term treatment of patients in remission causes CD8+-lymphocytes deficiency and high rates of CD4+/CD8+, CD3+/CD16+, IgЕ, IL-4. The course of reactive arthritis is accompanied by low content of CD3+-cells and unchanged immunoglobulin levels in peripheral blood. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|