Spectral-Domain and Swept-Source OCT Angiographic Scans Yield Similar Drusen Measurements When Processed with the Same Algorithm

Autor: Farhan E. Hiya, MD, Jeremy Y. Liu, MD, Mengxi Shen, MD, Gissel Herrera, MD, Jianqing Li, MD, Qinqin Zhang, PhD, Luis de Sisternes, PhD, Robert C. O'Brien, PhD, Philip J. Rosenfeld, PhD, MD, Giovanni Gregori, PhD
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Ophthalmology Science, Vol 4, Iss 3, Pp 100424- (2024)
Druh dokumentu: article
ISSN: 2666-9145
DOI: 10.1016/j.xops.2023.100424
Popis: Purpose: An algorithm developed to obtain drusen area and volume measurements using swept-source OCT angiography (SS-OCTA) scans was tested on spectral-domain OCT angiography (SD-OCTA) scans. Design: Retrospective study. Participants: Forty pairs of scans from 27 eyes with intermediate age-related macular degeneration and drusen. Methods: Patients underwent both SD-OCTA and SS-OCTA imaging at the same visit using the 6 mm × 6 mm OCTA scan patterns. Using the same algorithm, we obtained drusen area and volume measurements within both 3 mm and 5 mm fovea-centered circles. Paired 2-sample t-tests were performed along with Pearson’s correlation tests. Main Outcome Measures: Mean square root (sqrt) drusen area and cube root (cbrt) drusen volume within the 3 mm and 5 mm fovea-centered circles. Results: Mean sqrt drusen area values from SD-OCTA and SS-OCTA scans were 1.57 (standard deviation [SD] 0.57) mm and 1.49 (SD 0.58) mm in the 3 mm circle and 1.88 (SD 0.59) mm and 1.76 (SD 0.58) mm in the 5 mm circle, respectively. Mean cbrt drusen volume measurements were 0.54 (SD 0.19) mm and 0.51 (SD 0.20) mm in the 3 mm circle, and 0.60 (SD 0.17) mm and 0.57 (SD 0.17) mm in the 5 mm circle. Small differences in area and volume measurements were found (all P 0.97; all P
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