Neutralizing antibodies levels are increased in individuals with heterologous vaccination and hybrid immunity with Ad5-nCoV in the north of Mexico.

Autor: Karla Cervantes-Luevano, Astrid N Espino-Vazquez, Gonzalo Flores-Acosta, Johanna Bernaldez-Sarabia, Olivia Cabanillas-Bernal, Jahaziel Gasperin-Bulbarela, Ricardo Gonzalez-Sanchez, Andreu Comas-Garcia, Alexei F Licea-Navarro
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: PLoS ONE, Vol 17, Iss 6, p e0269032 (2022)
Druh dokumentu: article
ISSN: 1932-6203
16249496
DOI: 10.1371/journal.pone.0269032
Popis: The coordinated efforts to stop the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) include massive immunization of the population at a global scale. The humoral immunity against COVID-19 is conferred by neutralizing antibodies (NAbs) that occur during the post-infection period and upon vaccination. Here, we provide robust data showing that potent neutralizing antibodies are induced in convalescent patients of SARS-CoV-2 infection who have been immunized with different types of vaccines, and patients with no previous history of COVID-19 immunized with a mixed vaccination schedule regardless of the previous infection. More importantly, we showed that a heterologous prime-boost in individuals with Ad5-nCoV (Cansino) vaccine induces higher NAbs levels in comparison to a single vaccination scheme alone.
Databáze: Directory of Open Access Journals
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