| Autor: |
Uchechi E. Enenebeaku, Nnamdi C. Ukwandu, Ifeyinwa C. Mgbemena, Harriet C. Nwigwe, Conrad K. Enenebeaku, Chidi E. Duru, Odangowei I. Ogidi |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Bulletin of the National Research Centre, Vol 45, Iss 1, Pp 1-13 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2522-8307 |
| DOI: |
10.1186/s42269-021-00530-0 |
| Popis: |
Abstract Background Malaria is one of the tropical diseases of universal concern particularly with continuous appearance of resistant strains of P.falciparum. This calls for continous screening of traditional plants such that new and effective antimalarial agents will be developed. This study therefore explored the oral acute toxicity and antimalarial potentials of aqueous and methanolic extracts of roots, leaves and stem of Dictyandra arborescens on Plasmodium berghei infected mice. Results No mortality was recorded in any of the experimental animal groups even at the highest tested dose (5000 mg/kg b.wt) of the extract after monitoring them for 4hrs and subsequently for 7 days. Out of the six extracts, methanolic extracts of the roots and leaves exhibited more antimalarial activity than others. A significant difference (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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