| Autor: |
Mužíková Jitka, Komersová Alena, Lochař Václav, Vildová Lucie, Vošoustová Bára, Bartoš Martin |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Acta Pharmaceutica, Vol 68, Iss 3, Pp 295-311 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1846-9558 |
| DOI: |
10.2478/acph-2018-0030 |
| Popis: |
This paper evaluates and compares the properties of directly compressible tabletting materials and matrix tablets containing a combination of α-lactose monohydrate and microcrystalline cellulose in the 3:1 ratio in a physical mixture and in a coprocessed dry binder. Tested parameters include flow properties, compressibility, compactibility and the rate of drug release from tablets. Compressibility is evaluated by means of the energy profile of the compression process. Compactibility is evaluated by means of the tensile strength of the tablets. Dissolution testing is done using the rotating basket method. Dissolution profiles are evaluated by non-linear regression analysis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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