Diagnostic value of 8-isoprostane and transforming growth factor-β in bronchial asthma patients

Autor: Amgad Frahat, Yousef Mansour, Ayman Eldib, Doaa Alsed
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: The Egyptian Journal of Bronchology, Vol 12, Iss 3, Pp 295-302 (2018)
Druh dokumentu: article
ISSN: 1687-8426
2314-8551
DOI: 10.4103/ejb.ejb_18_17
Popis: Abstract Background Asthma is an airway inflammatory disease with functional and structural changes, leading to bronchial hyperreponsiveness and airflow obstruction. 8-Isoprostane (8-iso-PGF2α) is considered a marker of oxidative stress specific to lipid peroxidation, transforming growth factor β1 (TGFβ1) as an important fibrogenic and immunomodulatory factor known to induce structural changes associated with asthma. Objective We aimed to study the diagnostic value of 8-iso-PGF2α and TGFβ1 in asthmatic patients. Patients and methods Samples of serum and bronchoalveolar lavage fluid from 40 asthmatic patients (20 moderate and 20 severe) and 10 healthy volunteers were assessed for their levels of 8-iso-PGF2α and TGFβ1. Results Bronchoalveolar lavage 8-iso-PGF2α and TGFβ1 was higher in asthmatic patients. It was significantly increased with increased asthma severity. Conclusion Increased levels of TGFβ1 and 8-iso-PGF2α is associated with disease severity. However, there is need for continued exploration on the mechanisms responsible for these structural changes.
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