Zn(OAc)2•2H2O- Catalyzed Synthesis of Chromeno[2,3-d] Pyrimidinones under Solvent-free Conditions
| Autor: | P. Rama Krishna Veni, Ch. Vijaya Saradhi, G. Usha Rani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Current Chemistry Letters, Vol 13, Iss 4, Pp 677-682 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1927-7296 1927-730X |
| DOI: | 10.5267/j.ccl.2024.5.003 |
| Popis: | Due to their high synthetic efficiency, multi-component reactions (MCRs) have shown to be extraordinarily effective at producing compounds in a single synthetic operation. The chromeno[2,3-d] pyrimidine moieties represent important building blocks in synthetic bioactive compounds. The reaction of barbituric acid, aldehydes, and cyclohexane-1,3-diones in the presence of zinc acetate (5 mol%) under neat conditions at 70 0C, yielded a facile and one-pot synthesis of corresponding chromeno[2,3-d]pyrimidineones. Thirteen compounds containing neutral, withdrawing and electron donating groups (H, NO2, -CN, -Cl; -OH, -CH3 and -OCH3) were synthesized in good, isolated yields ranging from 78-91%. The successful involvement of o-, m-, and p- substituted nitro benzaldehydes suggested that steric hindrance had no effect. All of the synthesized compounds are well-known, and this process is unique in that it makes use of zinc acetate, an accessible, low-cost Lewis acid catalyst. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|