The effect of Ulinastatin on postoperative course in cardiopulmonary bypass patients in Asia: a meta-analysis of randomized controlled trials

Autor:	Hu Zhenyu, Yuan Qiaoli, Chen Guangxiang, Wang Maohua
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Ulinastatin Cardiopulmonary bypass Clinical outcome ICU length of stay Prognosis Acute inflammatory disorder Surgery RD1-811 Anesthesiology RD78.3-87.3
Zdroj:	Journal of Cardiothoracic Surgery, Vol 17, Iss 1, Pp 1-14 (2022)
Druh dokumentu:	article
ISSN:	1749-8090
DOI:	10.1186/s13019-022-01811-z
Popis:	Abstract Objectives To evaluate the effect of urinary trypsin inhibitor (UTI) or Ulinastatin on postoperative course and clinical outcomes in patients with cardiopulmonary bypass. Methods We searched PubMed, Embase, Web of Science, and Cochrane Library for the keywords UTI and Cardiopulmonary bypass (CPB). The primary outcome measure was the intensive care unit length of stay (ICU LOS), and results were stratified for relevant subgroups (dosage of UTI). The effects of UTI on mechanical ventilation duration (MVD), hospital LOS, renal failure incidence (RFI), and all-cause mortality were studied as secondary outcomes. Results Twelve randomized controlled trials (enrolling 1620 patients) were evaluated. Eleven studies pooled for subgroup analysis showed that using UTI persistently or with a considerable amount would lead to a shorter ICU LOS (95% CI, − 0.69 to − 0.06; P = 0.0001). Ten studies showed that UTI could shorten MVD in patients (95% CI, − 1.505 to − 0.473; P
Databáze:	Directory of Open Access Journals
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