Successful treatment of extensively drug-resistant Acinetobacter baumannii ventriculitis with polymyxin B and tigecycline- a case report

Autor: Wei Guo, Shao-Chun Guo, Min Li, Li-Hong Li, Yan Qu
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Antimicrobial Resistance and Infection Control, Vol 7, Iss 1, Pp 1-4 (2018)
Druh dokumentu: article
ISSN: 2047-2994
DOI: 10.1186/s13756-018-0313-5
Popis: Abstract Background Acinetobacter baumannii nosocomial ventriculitis/meningitis, especially those due to drug-resistant strains, has substantially increased over recent years. However, limited therapeutic options exist for the Acinetobacter baumannii ventriculitis/meningitis because of the poor penetration rate of most antibiotics through the blood-brain barrier. Case presentation A 57-year-old male patient developed ventriculitis from an extensively drug-resistant strain of Acinetobacter baumannii after the decompressive craniectomy for severe traumatic brain injury. The patient was successfully treated with intraventricular and intravenous polymyxin B together with intravenous tigecycline. Conclusions The case illustrates intraventricular polymyxin B can be a therapeutic option against extensively drug-resistant Acinetobacter baumannii ventriculitis.
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