Evaluation of Tumour Budding in Head and Neck Squamous Cell Carcinoma and Its Relationship with other Histological Parameters of Prognosis

Autor: Shreshtha Ghosh, Priyadarshini Guha
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Asian Pacific Journal of Cancer Biology, Vol 8, Iss 3, Pp 203-209 (2023)
Druh dokumentu: article
ISSN: 2538-4635
DOI: 10.31557/apjcb.2023.8.3.203-209
Popis: Background: Tumor budding (TB) is an emerging and promising histopathological prognostic parameter in oral squamous cell carcinoma (SCC). Tumour budding shows positive correlation with lymph node metastasis, higher pattern of invasion, high grade of tumor and more depth of invasion. These histopathological parameters are associated with poor prognosis, high rate of recurrence and these prognostic factors can be routinely used by clinicians for planning of multimodality treatment. Method: The present study was a cross-sectional study carried out on total of 239 patients with oral squamous cell carcinoma who attended the surgical oncology unit of Kalyan Singh Super Speciality Cancer Institute, Lucknow, Uttar Pradesh, India, from November 2020 to June 2022. Descriptive statistical analysis has been carried out in the present study. We used Fischer Exact Probability test and chi-square test analysis in order to identify relationship between different histological features, significance was considered when p1cm (100 cases). DOI was significantly associated with intensity of tumor budding (p
Databáze: Directory of Open Access Journals