Cyclic di-AMP Oversight of Counter-Ion Osmolyte Pools Impacts Intrinsic Cefuroxime Resistance in Lactococcus lactis

Autor: Huong Thi Pham, Wen Shi, Yuwei Xiang, Su Yi Foo, Manuel R. Plan, Pascal Courtin, Marie-Pierre Chapot-Chartier, Eddy J. Smid, Zhao-Xun Liang, Esteban Marcellin, Mark S. Turner
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: mBio, Vol 12, Iss 2 (2021)
Druh dokumentu: article
ISSN: 2150-7511
DOI: 10.1128/mBio.00324-21
Popis: The bacterial second messenger cyclic di-AMP (c-di-AMP) is a global regulator of potassium homeostasis and compatible solute uptake in many Gram-positive bacteria, making it essential for osmoregulation. The role that c-di-AMP plays in β-lactam resistance, however, is unclear despite being first identified a decade ago.
Databáze: Directory of Open Access Journals