Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer

Autor: A. S. Noman, M. Uddin, A. A. Chowdhury, M. J. Nayeem, Z. Raihan, M. I. Rashid, A. K. Azad, M. L. Rahman, D. Barua, A. Sultana, A. Shirin, J. Ferdous, R. R. Parag, S. M. Rahman, M. R. Mahmud, C. S. Jerin, N. Jahan, A. Siddiqua, T. Ara, E. B. Sabur, S. S. Alam, S. Baidya, S. Akther, M. Z. Rahman, T. Banu, A. K. Murugan, S. Sabri, S. M. S. Islam, B. Karakas, A. Aboussekhra, H. Yeger, W. A. Farhat, S. S. Islam
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Druh dokumentu: article
ISSN: 2045-2322
41158865
DOI: 10.1038/s41598-017-01268-4
Popis: Abstract Serum from one hundred and ten breast cancer patients and thirty healthy female volunteers, were prospectively collected and evaluated for serum levels of Shh and IL-6 using human Shh and IL-6 specific enzyme-linked immunoassays. All patients were regularly monitored for event free survival (EFS) and overall survival (OS). Overall outcome analysis was based on serum Shh and IL-6 levels. In patients with progressive metastatic BC, both serum Shh and IL-6 concentrations were elevated in 44% (29 of 65) and 63% (41 of 65) of patients, respectively, at a statistically significant level [Shh (p = 0.0001) and IL-6 (p = 0.0001)] compared to the low levels in healthy volunteers. Serum levels tended to increase with metastatic progression and lymph node positivity. High serum Shh and IL-6 levels were associated with poor EFS and OS opposite to the negative or lower levels in serum Shh and IL-6. The elevated levels of both serum Shh and IL-6 were mainly observed in BC patients who had a significantly higher risk of early recurrence and bone metastasis, and associated with a worse survival for patients with progressive metastatic BC. Further studies are warranted for validating these biomarkers as prognostic tools in a larger patient cohort and in a longer follow-up study.
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