Diagnostic Utility of TTF-1 and P40 Immunohistochemical Markers for Subtyping of Non-Small Cell Lung Carcinoma
| Autor: | Mayank Agrawal, Vibhuti Goyal, Anjana Arya, G D Katiyar, Nitesh Mohan |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Journal of Medical Sciences and Health, Vol 9, Iss 1, Pp 37-42 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2394-9481 2394-949X |
| DOI: | 10.46347/jmsh.v9i1.22.393 |
| Popis: | Background : Lung cancer is the leading cause of cancer-related mortality over worldwide. Although the pathological diagnosis of lung carcinoma is limited as only small specimen available for diagnosis, the availability of targeted therapies has created a need for precise subtyping of non-small cell lung carcinoma. Several recent studies have demonstrated that the use of immunohistochemical markers can be helpful in differentiating squamous cell carcinoma from adenocarcinoma not only on surgically resected specimen but also on small biopsy samples. Material and Methods: A cross-sectional study of one year duration including 50 cases of lung carcinomas on guided biopsies were first reported on Haematoxylin and Eosin sections and later subjected for IHC using relevant markers TTF-1 and p40. Results: In our study IHC with TTF-1 and p40 aided in subtyping of 35 (92.1%) cases of non-small cell lung carcinoma and this diagnostic accuracy was found to be statistically significant with p value |
| Databáze: | Directory of Open Access Journals |
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