| Autor: |
Sarah S Jackson, Marina Lex, Vanessa Van De Wyngard, Paz Cook, Allan Hildesheim, Ligia A Pinto, Sharon H Jackson, Kelvin Choi, Tsion Zewdu Minas, Héctor Fabio Losada Morales, Juan Carlos Araya, Catterina Ferreccio, Jill Koshiol, Ruth M Pfeiffer |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Future Science OA (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2056-5623 |
| DOI: |
10.2144/fsoa-2023-0032 |
| Popis: |
Aim: Statins are associated with lower risk of gallstones due to anti-inflammatory effects. We assessed whether statins impact circulating inflammation among Chilean women with gallstones. Materials & methods: 200 Mapuche women were matched on statin use and age to 200 non-Mapuche women in the Chile Biliary Longitudinal Study. We analyzed 92 inflammatory biomarkers using multivariable-adjusted regression models, random forests and pathway analyses. Results: Statins were not significantly associated with any inflammation marker when women were analyzed jointly or stratified by ancestry. No significant associations were found through random forest methods and pathway analyses. Discussion: We did not find significant associations between statin use and inflammation markers in women with gallstones, suggesting that statins do not reduce inflammation once gallstones have formed. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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