The Beneficial Effect of Three-month Induction Therapy with High-dose Prednisone and Mycophenolate Mofetil Followed by Maintenance Therapy in Acute Non-crescentic Nephritis Associated with Immunoglobulin A Deposition Disease in Adults
| Autor: | Kamel El-Reshaid, Shaikha Al-Bader, John Madda |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Saudi Journal of Kidney Diseases and Transplantation, Vol 34, Iss 2, Pp 161-166 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1319-2442 2320-3838 |
| DOI: | 10.4103/1319-2442.391895 |
| Popis: | The data available on immunoglobulin A (IgA) deposition disease indicate an inherited predisposition to the disease with autoimmune triggering. Hence, we prospectively evaluated the role of a new autoimmune regimen in the treatment of severe nephrotic or nephritic flares associated with noncrescentic nephritis in adult patients. Thirty-six patients were included, and the regimen consisted of an initial 3-month induction phase of prednisone and mycophenolate mofetil (MMF), followed by a maintenance phase of MMF alone for 21 months. Complete remission (CR) (normalization of creatinine clearance [CrCl] and a decrease in protein output to |
| Databáze: | Directory of Open Access Journals |
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