Simulation Model of Trabecular Bone Remodeling Considering Effects of Osteocyte Apoptosis and Targeted Remodeling

Autor: Jiyean KWON, Hisashi NAITO, Takeshi MATSUMOTO, Masao TANAKA
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Zdroj: Journal of Biomechanical Science and Engineering, Vol 5, Iss 5, Pp 539-551 (2010)
Druh dokumentu: article
ISSN: 1880-9863
DOI: 10.1299/jbse.5.539
Popis: Bone structure is renewed or restructured in part by a load-dependent remodeling. In this study, a mathematical model of bone surface remodeling over a wide range of strain was established. We assumed that in a low strain range, bone resorption occurs at an accelerated rate with strain decrease owing to low strain-induced osteocyte apoptosis, and that in a high strain range, bone formation occurs at an accelerated rate with strain increase (targeted remodeling). In a physiological strain range, bone formation or resorption was assumed to occur stochastically according to the degree of local stress non-uniformity. The utility of the present model was examined through three-dimensional numerical simulation of femoral trabecular architecture.
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