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Marwa Eissa,1,2 Sabry Shaarawy,3 Mona S Abdellateif3 1Internal Medicine and Endocrinology Department, Faculty of Medicine, Cairo University, Cairo, Egypt; 2Endocrinology Department, Faculty of Armed Forces of Medical College (AFMC), Cairo, Egypt; 3Medical Biochemistry and Molecular Biology, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, EgyptCorrespondence: Mona S AbdellateifMedical Biochemistry and Molecular Biology, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, 11976, EgyptFax + 202 23644720Email mona.sayed@nci.cu.edu.egAim: To assess the role of different inflammatory indices in the diagnosis of COVID-19 infection.Methods: The neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), derived NLR (dNLR), neutrophil to lymphocyte, platelet ratio (NLPR), systemic inflammation index (SII), aggregate index of systemic inflammation (AISI), systemic inflammation response index (SIRI) and C-reactive protein-to-lymphocyte ratio (CRP/L) were assessed in 88 COVID-19 patients compared to 41 healthy control subjects.Results: The NLR, PLR, NLPR, SIRI, and CRP/L were significantly increased, while LMR was significantly decreased in COVID-19 patients compared to the control group (P = 0.008, 0.011, < 0.001, 0.032, 0.002 and P < 0.001; respectively). The AUC for the assessed indices was LMR (0.738, P = 0.008), NLPR (0.721, P < 0.001), CRP/L (0.692, P = 0.002), NLR (0.649, P < 0.001), PLR (0.643, P = 0.011), SIRI (0.623, P = 0.032), dNLR (0.590, P = 0.111), SII (0.571, P = 0.207), and AISI (0.567, P-0.244). Multivariate analysis showed that NLPR > 0.011 (OR: 38.751, P = 0.014), and CRP/L > 7.6 (OR: 7.604, P = 0.022) are possible independent diagnostic factors for COVID-19 infection.Conclusion: NLPR and CRP/L could be potential independent diagnostic factors for COVID-19 infection.Keywords: COVID-19, C-reactive protein, lymphocytes, inflammatory index, platelets, SII |
