| Autor: |
Ricardo Calderón González, Hector Teran-Navarro, Jose Maria Marimon, Claudia Gonzalez-Rico, Jorge Calvo-Montes, Elisabet Frande Cabanes, Miriam Alkorta-Gurrutxaga, Carmen Fariñas, Luis Martinez-Martinez, Emilio Perez-Trallero, Carmen Alvarez-Dominguez |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Frontiers in Immunology, Vol 7 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
1664-3224 |
| DOI: |
10.3389/fimmu.2016.00541 |
| Popis: |
Two regions of northern Spain, Gipuzkoa and Cantabria present high annual incidence of listeriosis (1.86 and 1.71 cases per 100,000 inhabitants, respectively). We report that the high annual incidences are a consequence of infection with highly virulent L. monocytogenes isolates linked to fatal outcomes in elderly patients with cancer. In addition, listeriosis patients with cancer present low IL-17A/IL-6 ratios and significantly reduced levels of anti-GAPDH1-22 antibodies, identified as two novel biomarkers of poor prognosis. Analysis of these biomarkers may aid in reducing the incidence of listeriosis. Moreover, GAPDH1-22 activated monocyte derived dendritic cells of listeriosis patients with cancer seem useful tools to prepare clinical vaccines as they produce mainly Th1 cytokines. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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