COMPARATIVE STUDY OF EFFICIENCY AND SAFETY OF THE NEW DRUG OF AMLODOPINE – S-AMLODOPINE IN PATIENTS WITH ARTERIAL HYPERTENSION OF I-II DEGREE
| Autor: | M. A. Maksimova, Y. V. Lukina, S. N. Tolpygina, E. V. Shilova, N. A. Dmitrieva, S. Y. Martsevich |
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| Jazyk: | English<br />Russian |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Рациональная фармакотерапия в кардиологии, Vol 4, Iss 2, Pp 34-37 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1819-6446 2225-3653 |
| DOI: | 10.20996/1819-6446-2008-4-2-34-37 |
| Popis: | Aim. To evaluate efficacy and safety of a new drug of amlodipine – S-amlodipine (Azomex, Emcur, India) compared to original drug of racemic amlodipine (Norvasc, Pfizer, USA) in patients with arterial hypertension (HT) of I-II grade.Material and methods. 39 patients with HT of I-II grade were randomized into two groups and took drugs of amlodipine during 8 weeks. Ambulatory blood pressure monitoring (ABPM) was undertaken before treatment and at the end of treatment.Results. 34 patients completed 8-week therapy. Both drugs showed antihypertensive effect: significant decrease in average levels of systolic and diastolic blood pressure (BP) recorded by office and ABPM measurements. Compared to racemic amlodipine S-amlodipine caused bigger decrease in systolic and diastolic BP and bigger decrease in daily and 24-hour average diastolic BP after 4 week of therapy.Conclusion. S-amlodipine is effective antihypertensive drug, showing more significant BP decrease in comparison with this of racemic amlodipine after 4 weeks of treatment. |
| Databáze: | Directory of Open Access Journals |
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