Formulation and evaluation of niosomes-based chlorpheniramine gel for the treatment of mild to moderate skin allergy

Autor: Urooj Afreen, Khairi Mustafa Fahelelbom, Syed Nisar Hussain Shah, Akram Ashames, Uzma Almas, Shujaat Ali Khan, Muhammad Arfat Yameen, Naveed Nisar, Muhammad Hassham Hassan Bin Asad, Ghulam Murtaza
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Experimental Nanoscience, Vol 17, Iss 1, Pp 467-495 (2022)
Druh dokumentu: article
ISSN: 17458080
1745-8099
1745-8080
DOI: 10.1080/17458080.2022.2094915
Popis: Purpose of present study was to develop eight formulations of chlorpheniramine (CPM) niosomes according to 23 factorial design, characterise on the basis of various evaluation tests, i.e. in vitro drug release, SEM, FTIR, TGA and release kinetics, optimise the eight formulation on the basis in vitro drug release data, formulate gel of optimised dispersion, and to perform in vivo and histopathological study using gel of optimised dispersion on rabbits. Here, N3 having low level of cholesterol and span-80 but high level of span-60(0.1:0.2:0.05) was selected as optimised dispersion of niosomes that showed highest drug release i.e. 88.25% at pH 6 over 24 h of study and followed Korsmeyers-Peppas release kinetics with Fickian diffusion mechanism. After application of statistic by Analysis of variance (ANOVA) with 3D surface plots construction, gel of optimised dispersion of CPM niosomes was formulated, and evaluated by tests for i.e. viscosity, Spreadability, Extrudibility, drug content, drug entrapment, stability, SEM, FTIR, TGA, in vitro drug release, in vivo drug release following first order kinetics and histopathological study. Niosomal gel of CPM ensured successful development using suitable combination of non-ionic surfactants, and effective loading of drug for targeted delivery of drug.
Databáze: Directory of Open Access Journals
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