Academic outcomes before and after clinical onset of acquired demyelinating syndromes in children: a matched cohort data linkage study

Autor:	Michael Eyre, Michael Absoud, Omar Abdel‐Mannan, Sarah Crichton, Yael Hacohen, Thomas Rossor, Sarah Rudebeck, Gavin Giovannoni, Ming Lim, Cheryl Hemingway
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Zdroj:	Annals of Clinical and Translational Neurology, Vol 11, Iss 11, Pp 3025-3030 (2024)
Druh dokumentu:	article
ISSN:	2328-9503
DOI:	10.1002/acn3.52198
Popis:	Abstract It is unknown if cognition is impaired before clinical onset of paediatric acquired demyelinating syndromes. We conducted a matched cohort study using prospectively collected educational data in multiple sclerosis (MS) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD) patients (n = 60) and controls (pooled n = 449,553). Academic performance at ages 10–11 was impaired in MOGAD (−1.27 adjusted z‐score [95% CI: −1.81 to −0.73], P
Databáze:	Directory of Open Access Journals
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