Maternal Low-protein Diet Alters Ovarian Expression of Folliculogenic and Steroidogenic Genes and Their Regulatory MicroRNAs in Neonatal Piglets

Autor:	Shiyan Sui, Yimin Jia, Bin He, Runsheng Li, Xian Li, Demin Cai, Haogang Song, Rongkui Zhang, Ruqian Zhao
Jazyk:	angličtina
Rok vydání:	2014
Předmět:	Folliculogenesis Steroidogenesis Maternal Dietary Protein MicroRNA Ovary Neonatal Piglet Animal culture SF1-1100 Animal biochemistry QP501-801
Zdroj:	Asian-Australasian Journal of Animal Sciences, Vol 27, Iss 12, Pp 1695-1704 (2014)
Druh dokumentu:	article
ISSN:	1011-2367 1976-5517
DOI:	10.5713/ajas.2014.14335
Popis:	Maternal malnutrition during pregnancy may give rise to female offspring with disrupted ovary functions in adult age. Neonatal ovary development predisposes adult ovary function, yet the effect of maternal nutrition on the neonatal ovary has not been described. Therefore, here we show the impact of maternal protein restriction on the expression of folliculogenic and steroidogenic genes, their regulatory microRNAs and promoter DNA methylation in the ovary of neonatal piglets. Sows were fed either standard-protein (SP, 15% crude protein) or low-protein (LP, 7.5% crude protein) diets throughout gestation. Female piglets born to LP sows showed significantly decreased ovary weight relative to body weight (p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/a516272cfc2f480098dce6bf756bbf18 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF