Maternal Low-protein Diet Alters Ovarian Expression of Folliculogenic and Steroidogenic Genes and Their Regulatory MicroRNAs in Neonatal Piglets
Autor: | Shiyan Sui, Yimin Jia, Bin He, Runsheng Li, Xian Li, Demin Cai, Haogang Song, Rongkui Zhang, Ruqian Zhao |
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Jazyk: | angličtina |
Rok vydání: | 2014 |
Předmět: | |
Zdroj: | Asian-Australasian Journal of Animal Sciences, Vol 27, Iss 12, Pp 1695-1704 (2014) |
Druh dokumentu: | article |
ISSN: | 1011-2367 1976-5517 |
DOI: | 10.5713/ajas.2014.14335 |
Popis: | Maternal malnutrition during pregnancy may give rise to female offspring with disrupted ovary functions in adult age. Neonatal ovary development predisposes adult ovary function, yet the effect of maternal nutrition on the neonatal ovary has not been described. Therefore, here we show the impact of maternal protein restriction on the expression of folliculogenic and steroidogenic genes, their regulatory microRNAs and promoter DNA methylation in the ovary of neonatal piglets. Sows were fed either standard-protein (SP, 15% crude protein) or low-protein (LP, 7.5% crude protein) diets throughout gestation. Female piglets born to LP sows showed significantly decreased ovary weight relative to body weight (p |
Databáze: | Directory of Open Access Journals |
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