| Autor: |
Xian Wang, Qingyu Meng, Yawen Chen, Yanjun Zhang, Xiaohui Huang, Longquan Xiang, Haiyang Kong, Chunxi Wang, Xueyang Wang, Dekang Zhang |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Frontiers in Immunology, Vol 14 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1664-3224 |
| DOI: |
10.3389/fimmu.2023.1100725 |
| Popis: |
BackgroundWe explored the prognostic and immunogenic characteristics of iron pendant disease regulators in colon cancer to provide a scientific basis for the prediction of tumor prognosis-related markers and potential immunotherapeutic drug targets.MethodsRNA sequencing and matched complete clinical information of colon cancer (COAD) were retrieved from the UCSC Xena database, and genomic and transcriptomic data of colon cancer from the TCGA database were downloaded. Then univariate and multifactorial Cox regression were used to process these data. The prognostic factors were analyzed by single-factor and multi-factor Cox regression, followed by Kaplan-Meier survival curves with the aid of R software “survival” package. Then we use FireBrowse online analysis tool to analyze the expression variation of all cancer genes, and draw a histogram according to the influencing factors to predict the 1, 3, and 5 year survival rates of patients.ResultsThe results show that age, tumor stage and iron death score were significantly correlated with prognosis (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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