The Expression and Significance of Stem Cell Transcription Factor Sox2 in Lung Carcinoma
| Autor: | Wei XU, Yunyan WEI, Yaoxi TAN, Steven Yan CHENG, Jianqing WU |
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| Jazyk: | čínština |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Chinese Journal of Lung Cancer, Vol 16, Iss 11, Pp 591-595 (2013) |
| Druh dokumentu: | article |
| ISSN: | 1009-3419 1999-6187 |
| DOI: | 10.3779/j.issn.1009-3419.2013.11.05 |
| Popis: | Background and objective Transcription factor Sox2 remains the pluripotency of stem cell, participates in self-renew of cancer stem cell and plays important role during the initiation and development of various cancers. This study intends to investigate the expression and significance of Sox2 and Sox2 autoantibodies (Sox2-Ab) in tissue and serum of patients with non-small cell lung cancer (NSCLC). Methods Expression of Sox2 gene and protein was tested in 58 cases of NSCLC, 16 patients with other tumors and 20 cases of normal lung tissue specimens by quantitative PCR and immunohistochemical assay, respectively. Serum Sox2-Ab level was detected in 30 cases of NSCLC patients and 30 healthy controls by ELISA method. Clinical and pathological data from patients were collected and analyzed retrospectively. Results Expression levels of Sox2 mRNA and protein were higher in patient with NSCLC than other groups, with statistically significant differences (P |
| Databáze: | Directory of Open Access Journals |
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