Inappropriate activity of local renin-angiotensin-aldosterone system during high salt intake: impact on the cardio-renal axis
| Autor: | Sabrina Ribeiro Gonsalez, Fernanda Magalhães Ferrão, Alessandro Miranda de Souza, Jennifer Lowe, Lucienne da Silva Lara Morcillo |
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| Jazyk: | English<br />Portuguese |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Brazilian Journal of Nephrology, Vol 40, Iss 2, Pp 170-178 (2018) |
| Druh dokumentu: | article |
| ISSN: | 2175-8239 46258388 |
| DOI: | 10.1590/2175-8239-jbn-3661 |
| Popis: | ABSTRACT Although there is a general agreement on the recommendation for reduced salt intake as a public health issue, the mechanism by which high salt intake triggers pathological effects on the cardio-renal axis is not completely understood. Emerging evidence indicates that the renin-angiotensin-aldosterone system (RAAS) is the main target of high Na+ intake. An inappropriate activation of tissue RAAS may lead to hypertension and organ damage. We reviewed the impact of high salt intake on the RAAS on the cardio-renal axis highlighting the molecular pathways that leads to injury effects. We also provide an assessment of recent observational studies related to the consequences of non-osmotically active Na+ accumulation, breaking the paradigm that high salt intake necessarily increases plasma Na+ concentration promoting water retention |
| Databáze: | Directory of Open Access Journals |
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