Delivery of theophylline as dry powder for inhalation
| Autor: | Bing Zhu, Mehra Haghi, Anphy Nguyen, Mary Goud, Stewart Yeung, Paul M. Young, Daniela Traini |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Asian Journal of Pharmaceutical Sciences, Vol 10, Iss 6, Pp 520-527 (2015) |
| Druh dokumentu: | article |
| ISSN: | 1818-0876 65943678 |
| DOI: | 10.1016/j.ajps.2015.08.005 |
| Popis: | Theophylline (TP) is a very well established orally or intravenously delivered antiasthma drug with many beneficial effects. This study aims to improve asthma treatment by creating a dry powder inhalable (DPI) formulation of TP to be delivered directly to the lung, avoiding the side effects associated with conventional oral delivery. The DPI TP formulation was investigated for its physico-chemical characteristics using scanning electron microscopy, laser diffraction, thermal analysis and dynamic vapour sorption. Furthermore, aerosol performance was assessed using the Multi Stage Liquid Impinger (MSLI). In addition, a Calu-3 cell transport assay was conducted in vitro using a modified ACI to study the impact of the DPI formulation on lung epithelial cells. Results showed DPI TP to be physico-chemically stable and of an aerodynamic size suitable for lung delivery. The aerosolisation performance analysis showed the TP DPI formulation to have a fine particle fraction of 29.70 ± 2.59% (P |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|