Effect of transjugular intrahepatic portosystemic shunt on transarterial chemoembolization for hepatocellular carcinoma: a systematic review and meta-analysis

Autor: Xi Chen, Zhen-Kang Qiu, Guo-Bao Wang, Xin-Lin Chen, Fu-Jun Zhang, Fei Gao
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Diagnostic and Interventional Radiology, Vol 27, Iss 5, Pp 671-676 (2021)
Druh dokumentu: article
ISSN: 1305-3825
1305-3612
DOI: 10.5152/dir.2021.20358
Popis: PURPOSEHepatocellular carcinoma (HCC) usually occurs accompanied by portal hypertension. Transcatheter arterial chemoembolization (TACE) is recommended as an effective treatment in HCC. Recent studies had conflicting results regarding the effectiveness and safety of TACE for HCC in patients with transjugular intrahepatic portosystemic shunt (TIPS). This meta-analysis aimed to evaluate the influence of TIPS on the effectiveness and safety of TACE for patients with HCC.METHODSA comprehensive search of studies among PubMed, Web of Science and Cochrane Library was conducted, from the earliest publishing date to January 27th, 2020. Statistical analyses were all performed using the Stata 13.0 software. I2 index statistic was used to assess heterogeneity.RESULTSSix studies with a total of 536 patients with HCC were included in the analysis. The pooled response rate was 51% (95% CI: 25% to 77%) with a significant heterogeneity (I2=93.3%, p < 0.001). The TACE + TIPS group had an inferior response rate than the non-TIPS group, but the difference had no statistical significance (p = 0.171) and heterogeneity was low (I2=0.00%, p = 0.490). Pooled hepatic failure rate was 8.8% (95% CI: 5.2% to 12.4%) with low heterogeneity (I2=0.0%, p = 0.747). But the pooled hepatic failure rate increased to 12.7% (95% CI: 5.7% to 19.7%) with low heterogeneity (I2=11.5%, p = 0.323) if the patients who received TIPS after TACE were excluded.CONCLUSIONTIPS does not influence the effectiveness of TACE, but attention should be paid to the risk of hepatic failure.
Databáze: Directory of Open Access Journals