Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma

Autor: Xue-Ke Zhao, Pengwei Xing, Xin Song, Miao Zhao, Linxuan Zhao, Yonglong Dang, Ling-Ling Lei, Rui-Hua Xu, Wen-Li Han, Pan-Pan Wang, Miao-Miao Yang, Jing-Feng Hu, Kan Zhong, Fu-You Zhou, Xue-Na Han, Chao-Long Meng, Jia-Jia Ji, Xingqi Chen, Li-Dong Wang
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-26745-3
Popis: The role of focal amplifications and extrachromosomal DNA (ecDNA) is unknown in gastric cardia adenocarcinoma (GCA). Here, the authors identify frequent focal amplifications and ecDNAs in Chinese GCA patient samples, as well as the potential associations of these alterations with prognosis and dietary habits.
Databáze: Directory of Open Access Journals