Cardio‐microcurrent device for chronic heart failure: first‐in‐human clinical study

Autor: Dragana Kosevic, Dominik Wiedemann, Petar Vukovic, Velibor Ristic, Julia Riebandt, Una Radak, Kersten Brandes, Peter Goettel, Hans‐Dirk Duengen, Elvis Tahirovic, Tatjana Kottmann, Hans Werner Voss, Marija Zdravkovic, Svetozar Putnik, Jan D. Schmitto, Johannes Mueller, Jesus Eduardo Rame, Miodrag Peric
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: ESC Heart Failure, Vol 8, Iss 2, Pp 962-970 (2021)
Druh dokumentu: article
ISSN: 2055-5822
DOI: 10.1002/ehf2.13242
Popis: Abstract Aims Most devices for treating ambulatory Class II and III heart failure are linked to electrical pulses. However, a steady electric potential gradient is also necessary for appropriate myocardial performance and may be disturbed by structural heart diseases. We investigated whether chronic application of electrical microcurrent to the heart is feasible and safe and improves cardiac performance. The results of this study should provide guidance for the design of a two‐arm, randomized, controlled Phase II trial. Methods and results This single‐arm, non‐randomized pilot study involved 10 patients (9 men; mean age, 62 ± 12 years) at two sites with 6 month follow‐up. All patients had New York Heart Association (NYHA) Class III heart failure and non‐ischaemic dilated cardiomyopathy, with left ventricular ejection fraction (LVEF)
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