25-hydroxyvitamin D levels are inversely related to metabolic syndrome risk profile in northern Chinese subjects without vitamin D supplementation

Autor: Hanyuan Xu, Guiyan Han, Linjie Wang, Huihua Ding, Chunyan Wang, Xiaochuan Ping, Caixia Dong, Dianxi Zhang, Yufei Dai, Naishi Li, Yufeng Li, Hongbo Yang, Huijuan Zhu, Hui Pan, Fengying Gong, Jichun Chen, Xiaoping Xing
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Diabetology & Metabolic Syndrome, Vol 14, Iss 1, Pp 1-11 (2022)
Druh dokumentu: article
ISSN: 1758-5996
DOI: 10.1186/s13098-022-00793-1
Popis: Abstract Background The comparatively low 25 hydroxyvitamin D [25(OH)D] levels have been reported in patients with metabolic syndrome (MetS). Herein we investigated the cross-sectional and longitudinal relationships between serum 25(OH)D levels and MetS risk profile in northern middle-aged Chinese subjects without vitamin D supplementation. Methods A cohort of 211 participants including 151 MetS patients and 60 controls at 20–69 years of age were enrolled from suburban Beijing, China. The recruited MetS patients were subjected to diet and exercise counselling for 1-year. All subjects at baseline and MetS patients after intervention underwent clinical evaluations. Results Serum 25(OH)D levels were significantly decreased in MetS patients. 25(OH)D levels were inversely related to MetS score, fasting blood glucose (FBG) and triglyceride-glucose index (TyG) after adjusting for cofounders (all P
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