| Autor: |
Prakash Chaudhary, Seung Joo Kim, Sadan Dahal, Shambhu Joshi, Sung Bum Son, Soo Young Kim, Sung-Hwan Eom, Kyung Tae Kim, Jung-Ae Kim |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Journal of Functional Foods, Vol 109, Iss , Pp 105795- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2023.105795 |
| Popis: |
Obtaining extracts rich in pharmacological components from edible brown seaweeds is essential for their use as functional foods or therapeutic supplements. The present study demonstrated that the cold-water extract of Hizikia fusiformis (HF-C) with a unique composition, unlike hot-water (HF-H) or acid (HF-A) extracts, inhibited NF-κB activation, pro-inflammatory cytokines and glucose transporter expression, and inflammatory glycolysis more than HF-H or HF-A did. Oral administration of HF-C significantly inhibited dextran sodium sulfate-induced colitis in mouse, as evidenced by a decrease in disease activity index and inflammatory cytokine expression, and recovered colonic tissue E-cadherin expression and body weight. Notably, the anti-colitis effect of HF-C was greater than sulfasalazine, an inflammatory bowel disease (IBD) drug. Taken together, the higher anti-inflammatory action of HF-C was due to the different composition of fucoidan compared to the other extracts. Consequently, the results suggest that HF-C may be a therapeutic adjunct to the treatment of IBD. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
Full Text from ScienceDirect