Reversible switch from hemoglobin A to C in sheep and recovery from anemia following experimental infection with Anaplasma ovis
| Autor: | Elisa Pieragostini, Ferruccio Petazzi, Anna Caroli, Alessandra Torina, Giuseppe De Ruvo, Ingrid Alloggio |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Italian Journal of Animal Science, Vol 8, Iss 2s, Pp 27-29 (2010) |
| Druh dokumentu: | article |
| ISSN: | 1594-4077 1828-051X |
| DOI: | 10.4081/ijas.2009.s2.27 |
| Popis: | Anemia causes a change in the type of circulating hemoglobin (Hb) in sheep carrying the βA-globin haplotype, where the Hb A is replaced with Hb C, unlike Hb B. The effect of the substitution of Hb A with Hb C on the recovery from anemia was investigated by comparing the hematological picture of sheep, following experimental infection with Anaplasma ovis. The blood values were obtained from 3 AB and 3 BB Hb sheep after the development of the disease where anemia is a pathognomonic symptom. The expression of the silent gene encoding for Hb C was detected by isoelectric focusing and quantified by high performance liquid chromatography. Both Hb AB genotype and Hb C occurrence were involved in the lower recovery from anemia in the trial. |
| Databáze: | Directory of Open Access Journals |
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