| Autor: |
Ingrid González-Casacuberta, Dolores Vilas, Claustre Pont-Sunyer, Ester Tobías, Judith Cantó-Santos, Laura Valls-Roca, Francesc Josep García-García, Glòria Garrabou, Josep Maria Grau-Junyent, Maria Josep Martí, Francesc Cardellach, Constanza Morén |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 17, Iss 3 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| Popis: |
Neurodegenerative diseases, such as Parkinson’s disease, are heterogeneous disorders with a multifactorial nature involving impaired bioenergetics. Stem-regenerative medicine and bioenergetics have been proposed as promising therapeutic targets in the neurologic field. The rationale of the present study was to assess the potential of human-derived adipose stem cells (hASCs) to transdifferentiate into neuronal-like cells (NhASCs and neurospheres) and explore the hASC bioenergetic profile. hASC neuronal transdifferentiation was performed through neurobasal media and differentiation factor exposure. High resolution respirometry was assessed. Increased MAP-2 neuronal marker protein expression upon neuronal induction (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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