Value of Tumor's Depth and Width in Predicting Survival Rate in Non-Muscle-Invasive (pT1) Bladder Cancer

Autor: Albert, Kevin Anthony Glorius Tampubolon, Sawkar Vijay Pramod, Ferry Safriadi
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: The Annals of African Surgery, Vol 19, Iss 4, Pp 180-185 (2022)
Druh dokumentu: article
ISSN: 1999-9674
2523-0816
DOI: 10.4314/aas.v19i4.4
Popis: Background: Bladder cancer is classified according to traditional American Joint Committee on Cancer TNM staging. In the absence of nodal (N stage) or distant metastases (M stage), the depth of tumor invasion (T stage) is the most important determination to be made: whether the tumor is invading into or beyond the lamina propria (muscle-invasive bladder cancer) or not (non-muscle-invasive bladder cancer). This study investigated the association between the cutoff value of tumor depth and width and survival rate in non-muscle-invasive (pT1) bladder cancer. Methods: This was a retrospective cohort design of randomly selected, single-centered study. The subjects were patients with pT1 urothelial carcinoma who were diagnosed on transurethral resection of bladder specimens at a tertiary hospital in West Java, Indonesia. The research sample was taken by consecutive sampling from 2015 to 2019. Results: Sixty-four patients from were included in this study. A tumor depth >2 mm resulted in a hazard ratio (HR) of 1.41 (95% confidence interval [CI], 1.27–3.94; p2.4 mm also increased HR significantly (3.27; 95% CI, 1.69–5.87; p
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