Schinus molle Resin Essential Oil as Potent Bioinsecticide Against Tribolium castaneum: Chemical Profile, In Vitro Acetylcholinesterase Inhibition, DFT Calculation and Molecular Docking Analysis

Autor: Wiem Baccari, Ilyes Saidi, Achref Jebnouni, Safa Teka, Sayda Osman, Awatif Mansoor Alrasheeday, Nuzaiha Mohamed, Mabrouka El Oudi, Hichem Ben Jannet
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Biomolecules, Vol 14, Iss 11, p 1464 (2024)
Druh dokumentu: article
ISSN: 2218-273X
DOI: 10.3390/biom14111464
Popis: Plants offer a bountiful source of natural pest control solutions through their essential oils. This research introduces and analyzes an eco-friendly natural essential oil for red flour beetle control. Therefore, the current study was included to show the chemical profile and the insecticidal efficacy of resin essential oil (REO) and its fractions (F1–3), resulting from chromatographic separation, from the plant Schinus molle against Tribolium castaneum adults. The trunk bark resin essential oil and its fractions’ composition were analyzed by GC-MS. Overall, 33 constituents with 98.3% of the total EO composition were identified. REO and F1–3 displayed impressive repellent properties at a concentration of 0.12 µL/cm2. After 120 min of exposure, repellency ranged from 73.3% to a remarkable 96.7%. They also exhibited noteworthy fumigant properties, with median lethal doses of LD50 = 120.6–160.8 μL/L. The fractions F1 and F3 showed the most notable topical toxicity at a concentration of 10%, with LD50 values of 8.6% and 5.6%, respectively. Fractions F3 and F2 demonstrated the most effective inhibition of acetylcholinesterase (AChE) activity, providing insight into their insecticidal mechanisms. The in silico molecular docking and DFT studies corroborate the results of in vitro tests performed to identify new insecticide products derived from natural sources.
Databáze: Directory of Open Access Journals
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