Development of a multiparticulate system containing enteric-release mini-tablets of omeprazole

Autor:	Volnei Jose Tondo Filho, Itamar Francisco Andreazza, Mayumi Elisa Otsuka Sato, Fábio Seigi Murakami
Jazyk:	angličtina
Rok vydání:	2014
Předmět:	Sistema multiparticulado/liberação modificada Mini-comprimidos de liberação entérica/desenvolvimento Mini-comprimidos de liberação entérica/avaliação Omeprazol/dissolução Pharmacy and materia medica RS1-441
Zdroj:	Brazilian Journal of Pharmaceutical Sciences, Vol 50, Iss 3, Pp 505-511 (2014)
Druh dokumentu:	article
ISSN:	2175-9790 1984-8250
DOI:	10.1590/S1984-82502014000300008
Popis:	The main aim of this study was to develop a multiparticulate system containing mini-tablets of omeprazole formulated with an enteric polymer with pH-dependent solubility. Pre-formulation studies showed good flow and compaction capacity, leading to the production ofhigh quality mini-tablets. The mini-tablets were coated in a fluidized bed with hydroxypropylmethylcellulose /Eudragit(r) L30D55 and packed into hard gelatin capsules. The dissolution profile showed gastro-resistance and zero-order kinetics. The dissolution profile for the formulation containing lactose as the diluent and coated with 12% (tablet weight gain) of polymer was similar to that ofthe reference drug.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/50df9491e1744a5cb4873c6f81957008 Zobrazit plný text záznamu View record in DOAJ