Cellular Immune Status Indicators of Anti-Plague Vaccinated Persons, Living on the Caspian Sandy Natural Plague Focus Territory
| Autor: | A. L. Kravtsov, V. A. Kozhevnikov, S. N. Klyueva, O. M. Kudryavtseva, T. N. Schukovskaya, N. I. Mikshis, S. A. Bugorkova |
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| Jazyk: | ruština |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Эпидемиология и вакцинопрофилактика, Vol 18, Iss 4, Pp 67-74 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2073-3046 2619-0494 |
| DOI: | 10.31631/2073-3046-2019-18-4-67-74 |
| Popis: | Aim. To compare by flow cytometry the cellular immune status indicators in persons, living on the territory of the Caspian sandy natural plague focus for epidemic indications. Materials and methods. Whole blood leukocytes of 120 people were examined by flow cytometry with using the two four-color labeled monoclonal antibody reagents (Cyto-Stat CD45-FITC, CD4-PE, CD8-ECD, CD3-PC5 и Cyto-Stat CD45-FITC, CD56-PE, CD19-ECD, CD3-PC5) and by means of CD95-FITC reagent. The results were taken into account before and in a month and 6 months after vaccination. We were determined in the blood the relative content of lymphocytes, monocytes, granulocytes, leukocytes carrying an early apoptosis marker (CD95), T and B- lymphocytes, NK cells as well T – lymphocyte helpers (Th) and cytotoxic T-lymphocytes (Tcyt) for immunoregulatory index (IRI) calculation. Results. Before anti-plague vaccination in 14 people (11,7%) were found abnormally low immunoregulatory index values characterized the immunodeficiency state (IRI |
| Databáze: | Directory of Open Access Journals |
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