Copper-Catalyzed Trifluoromethylation of Alkoxypyridine Derivatives

Autor:	Nandor Gyorfi, Emese Farkas, Norbert Nemet, Csaba Weber, Zoltan Novak, Andras Kotschy
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	trifluoromethylation copper catalysis heterocycles Organic chemistry QD241-441
Zdroj:	Molecules, Vol 25, Iss 20, p 4766 (2020)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules25204766
Popis:	The trifluoromethylation of aromatic and heteroaromatic cores has attracted considerable interest in recent years due to its pharmacological relevance. We studied the extension of a simple copper-catalyzed trifluoromethylation protocol to alkoxy-substituted iodopyridines and their benzologs. The trifluoromethylation proceeded smoothly in all cases, and the desired compounds were isolated and characterized. In the trifluoromethylation of 3-iodo-4-methoxyquinoline, we observed a concomitant O-N methyl migration, resulting in the trifluoromethylated quinolone as a product. Overall, the described procedure should facilitate the broader use of copper-catalyzed trifluoromethylation in medicinal chemistry.
Databáze:	Directory of Open Access Journals
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