| Autor: |
Umut Kocabaş, Tarık Kıvrak, Gülsüm Meral Yılmaz Öztekin, Veysel Ozan Tanık, Ibrahim Halil Özdemir, Ersin Kaya, Elif Ilkay Yüce, Fulya Avcı Demir, Mustafa Doğduş, Meltem Altınsoy, Songül Üstündağ, Ferhat Özyurtlu, Uğur Karagöz, Alper Karakuş, Örsan Deniz Urgun, Ümit Yaşar Sinan, Inan Mutlu, Taner Şen, Mehmet Ali Astarcıoğlu, Mustafa Kınık, Özge Özden Tok, Begüm Uygur, Mehtap Yeni, Bahadır Alan, Onur Dalgıç, Çağla Sarıtürk, Hakan Altay, Seçkin Pehlivanoğlu |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Anatolian Journal of Cardiology, Vol 24, Iss 1, Pp 32-40 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2149-2263 |
| DOI: |
10.14744/AnatolJCardiol.2020.91771 |
| Popis: |
Objective: Despite recommendations from heart failure guidelines on the use of pharmacologic and device therapy in patients with heart failure with reduced ejection fraction (HFrEF), important inconsistencies in guideline adherence persist in practice. The aim of this study was to assess adherence to guideline-directed medical and device therapy for the treatment of patients with chronic HFrEF (left ventricular ejection fraction ≤40%). Methods: The Adherence to guideline-directed medical and device Therapy in outpAtients with HFrEF (ATA) study is a prospective, multicenter, observational study conducted in 24 centers from January 2019 to June 2019. Results: The study included 1462 outpatients (male: 70.1%, mean age: 67+-11 years, mean LVEF: 30%+-6%) with chronic HFrEF. Renin–angiotensin system (RAS) inhibitors, beta-blockers, mineralocorticoid receptor antagonists (MRAs), and ivabradin were used in 78.2%, 90.2%, 55.4%, and 12.1% of patients, respectively. The proportion of patients receiving target doses of medical treatments was 24.6% for RAS inhibitors, 9.9% for beta-blockers, and 10.5% for MRAs. Among patients who met the criteria for implantable cardioverter–defibrillator (ICD) and cardiac resynchronization therapy (CRT), only 16.9% of patients received an ICD (167 of 983) and 34% (95 of 279) of patients underwent CRT (95 of 279). Conclusion: The ATA study shows that most HFrEF outpatients receive RAS inhibitors and beta-blockers but not MRAs or ivabradin when the medical reasons for nonuse, such as drug intolerance or contraindications, are taken into account. In addition, most eligible patients with HFrEF do not receive target doses of pharmacological treatments or guideline-recommended device therapy. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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