Macrophage: Hidden Criminal in Therapy Resistance

Autor: Yimin Ding, Qian Cao, Wenjuan Yang, Junjie Xu, Peng Xiao
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Innate Immunity, Vol 16, Iss 1, Pp 188-202 (2024)
Druh dokumentu: article
ISSN: 1662-8128
00053821
DOI: 10.1159/000538212
Popis: Background: Although substantial efforts have been made by researchers to develop drugs, a disappointing reality is that the emergence of drug resistance is an unavoidable reality for the majority of patients. In recent years, emerging evidence suggests a connection between drug resistance and immune dysregulation. Summary: As a ubiquitously distributed, versatile innate immune cell, macrophages play essential roles in maintaining tissue homeostasis in a steady state. Nevertheless, it is becoming aware that macrophages undermine the action of therapeutic drugs across various disease types. Reprogramming macrophage function has been proven to be effective in restoring patient responsiveness to treatment. Herein, we comprehensively reviewed how macrophages respond to drugs and the mechanisms by which they contribute to treatment unresponsiveness in cancer, inflammatory diseases, and metabolic diseases. In addition, future prospects in macrophage-based combination therapy were discussed. Key Messages: Targeting macrophages is a promising strategy for overcoming drug resistance in immune disorders.
Databáze: Directory of Open Access Journals
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