| Autor: |
Drielly A. Paixão, Leticia P. de Oliveira, Pedro Ivo da S. Maia, Victor M. Deflon, Zumira A. Carneiro, Katia Júlia de Almeida, Norberto P. Lopes, Marcos Pivatto, Joana Darc S. Chaves, Sérgio de Albuquerque, Mauro V. de Almeida, Silvana Guilardi, Wendell Guerra |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Journal of Saudi Chemical Society, Vol 22, Iss 7, Pp 809-815 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1319-6103 |
| DOI: |
10.1016/j.jscs.2018.01.002 |
| Popis: |
We report here the characterization of two new polymeric copper(II) complexes containing 2-chlorobenzhydrazide (2-CH) and two N,N-donor ligands, namely, 1,10-phenanthroline (phen) and 4-4′-dimethoxy-2-2′-bipyridine (dmb). The structure of a new polymeric copper(II) complex in which a perchlorate anion acts as a bridge ligand is discussed in detail. In both complexes, spectral data reveals a bidentate coordination mode for hydrazide, perchlorate and N,N-donor ligand. These metal complexes and their free ligands were evaluated for their trypanocidal and cytotoxic activities and the complex with 1,10-phenanthroline has been much more active than benznidazole, a drug used in the treatment of Chagas disease. Keywords: Copper(II) complexes, Crystal structure, Trypanosoma cruzi, Cytotoxic activity |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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