Effects of interleukin-12 gene polymorphism on response to hepatitis B vaccination among hemodialysis Egyptian patients

Autor: Sawsan M Abdel-Moniem, Mohammed A Mohammed, Ziyad M Essam El-Deen, Hanan M Mostafa
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: The Egyptian Journal of Internal Medicine, Vol 31, Iss 4, Pp 804-812 (2019)
Druh dokumentu: article
ISSN: 1110-7782
2090-9098
DOI: 10.4103/ejim.ejim_85_19
Popis: Background Hepatitis B virus (HBV) infection is a major health problem among hemodialysis (HD) patients. Interleukin (IL)-12 gene polymorphisms may be associated with immune response variability to recombinant HBV vaccines. The aim was to determine the correlation between IL-12 gene polymorphism and hepatitis B surface-antibody (HBs-Ab) titer in response to HBV vaccine among HD Egyptian patients. Patients and methods Seventy patients receiving long-term HD and 20 age-matched and sex-matched healthy controls were enrolled. All participants were non-HBV vaccinated and seronegative for HBV and HIV. Recombinant HBV vaccine was given (three-dose scheduled). Thereafter, HBs-Ab titer and IL-12 gene polymorphism were evaluated 8 weeks after the last vaccination dose. Results There was no response (HBs-Ab0.05 for all). Conclusion There was no significant association between IL-12B gene polymorphism and HBs-Ab response in Egyptian HD patients. In HD patients, lymphocytopnea, diabetes mellitus (DM), high transferrin saturation and inefficient HD were associated with HBV vaccine hyporesponsiveness.
Databáze: Directory of Open Access Journals
Externí odkaz: