Differentiating and quantifying exosome secretion from a single cell using quasi-bound states in the continuum
| Autor: | Ndao Abdoulaye, Hsu Liyi, Cai Wei, Ha Jeongho, Park Junhee, Contractor Rushin, Lo Yuhwa, Kanté Boubacar |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Nanophotonics, Vol 9, Iss 5, Pp 1081-1086 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2192-8606 2192-8614 |
| DOI: | 10.1515/nanoph-2020-0008 |
| Popis: | One of the key challenges in biology is to understand how individual cells process information and respond to perturbations. However, most of the existing single-cell analysis methods can only provide a glimpse of cell properties at specific time points and are unable to provide cell secretion and protein analysis at single-cell resolution. To address the limits of existing methods and to accelerate discoveries from single-cell studies, we propose and experimentally demonstrate a new sensor based on bound states in the continuum to quantify exosome secretion from a single cell. Our optical sensors demonstrate high-sensitivity refractive index detection. Because of the strong overlap between the medium supporting the mode and the analytes, such an optical cavity has a figure of merit of 677 and sensitivity of 440 nm/RIU. Such results facilitate technological progress for highly conducive optical sensors for different biomedical applications. |
| Databáze: | Directory of Open Access Journals |
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