| Autor: |
Sara B Mahmoud, Nesma A.M Salem, Olfat G Shaker, Aya M Fahim |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Journal of the Egyptian Women’s Dermatologic Society, Vol 20, Iss 3, Pp 162-167 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2090-2565 |
| DOI: |
10.4103/jewd.jewd_18_23 |
| Popis: |
Background Psoriasis is a chronic, inflammatory, T-cell-mediated autoimmune disease. Vitiligo is an acquired depigmentary disease that occurs due to the loss of functional melanocytes from the epidermis. Interleukin (IL)-9 is a T cell-derived cytokine that was initially designated as a T helper2 cytokine. There is a link between the expression and action of IL-9 and pro-inflammatory cytokines tumor necrosis factor, IL-1, IL-17, and interferon-γ, suggesting that IL-9 is associated with the pathogenesis of autoimmune diseases. Objective To evaluate the tissue levels of IL-9 in patients with psoriasis and vitiligo in comparison with controls, to assess the possible role of IL-9 in the pathogenesis of these diseases. Patients and methods This case–control study included 30 patients with psoriasis, 30 patients with vitiligo, and 30 age-matched and sex-matched healthy controls. A skin biopsy was taken from all participants for evaluation of tissue IL-9 levels by enzyme-linked immunosorbent assay. Results Tissue IL-9 was significantly higher in patients with psoriasis (28.65±18.456) and patients with vitiligo (51.056±41.536) than controls (P=0.013 and P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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