| Autor: |
Pooja Srivastava, Tiannan Wang, Beth Z. Clark, Jing Yu, Jeffrey L. Fine, Tatiana M. Villatoro, Gloria J. Carter, Adam M. Brufsky, Vikram C. Gorantla, Shannon L. Huggins-Puhalla, Leisha A. Emens, Thais Basili, Edaise M. da Silva, Jorge S. Reis-Filho, Rohit Bhargava |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
npj Breast Cancer, Vol 8, Iss 1, Pp 1-10 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2374-4677 |
| DOI: |
10.1038/s41523-022-00415-z |
| Popis: |
Abstract Triple-negative breast cancers (TNBCs) often have a high Ki-67 proliferation index and respond favorably to neoadjuvant chemotherapy (NACT) with pathologic complete response (pCR) resulting in ~40% of cases. Nevertheless, morbidity/mortality remain high, mostly due to recurrence in patients with residual disease. In contrast, the incidence and clinical features of TNBC with low proliferation (TNLP), defined as TNBC with a Ki-67 index of ≤30% remains unknown. We report 70 cases of TNLP identified at our center from 2008 to 2018, including 18 treated with NACT. TNLP tumors represent |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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