Cognitive impairment in long-COVID and its association with persistent dysregulation in inflammatory markers
| Autor: | Rodolfo Furlan Damiano, Cristiana Castanho de Almeida Rocca, Antonio de Pádua Serafim, Jennifer M. Loftis, Leda Leme Talib, Pedro Mário Pan, Edecio Cunha-Neto, Jorge Kalil, Gabriela Salim de Castro, Marilia Seelaender, Bruno F. Guedes, Suely K. Nagahashi Marie, Heraldo Possolo de Souza, Ricardo Nitrini, Euripedes Constantino Miguel, Geraldo Busatto, Orestes V. Forlenza, HCFMUSP COVID-19 Study Group, Edivaldo M. Utiyama, Aluisio C. Segurado, Beatriz Perondi, Anna Miethke-Morais, Amanda C. Montal, Leila Harima, Solange R. G. Fusco, Marjorie F. Silva, Marcelo C. Rocha, Izabel Marcilio, Izabel Cristina Rios, Fabiane Yumi Ogihara Kawano, Maria Amélia de Jesus, Ésper G. Kallas, Carolina Carmo, Clarice Tanaka, Julio F. M. Marchini, Carlos R. Carvalho, Juliana C. Ferreira, Anna Sara Levin, Maura Salaroli Oliveira, Thaís Guimarães, Carolina dos Santos Lázari, Alberto José da Silva Duarte, Ester Sabino, Marcello M. C. Magri, Tarcisio E. P. Barros-Filho, Maria Cristina Peres Braido Francisco |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Frontiers in Immunology, Vol 14 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2023.1174020 |
| Popis: | ObjectiveTo analyze the potential impact of sociodemographic, clinical and biological factors on the long-term cognitive outcome of patients who survived moderate and severe forms of COVID-19.MethodsWe assessed 710 adult participants (Mean age = 55 ± 14; 48.3% were female) 6 to 11 months after hospital discharge with a complete cognitive battery, as well as a psychiatric, clinical and laboratory evaluation. A large set of inferential statistical methods was used to predict potential variables associated with any long-term cognitive impairment, with a focus on a panel of 28 cytokines and other blood inflammatory and disease severity markers.ResultsConcerning the subjective assessment of cognitive performance, 36.1% reported a slightly poorer overall cognitive performance, and 14.6% reported being severely impacted, compared to their pre-COVID-19 status. Multivariate analysis found sex, age, ethnicity, education, comorbidity, frailty and physical activity associated with general cognition. A bivariate analysis found that G-CSF, IFN-alfa2, IL13, IL15, IL1.RA, EL1.alfa, IL45, IL5, IL6, IL7, TNF-Beta, VEGF, Follow-up C-Reactive Protein, and Follow-up D-Dimer were significantly (p |
| Databáze: | Directory of Open Access Journals |
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