Minimum inhibitory concentration of silver nanoparticle against Staphylococcus aureus and its relation with Methicillin resistance and bacterial source of isolation
| Autor: | F Azadi, A Jamali, B Baei, M Bazouri, F Shakeri, E Ghaemi |
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| Jazyk: | perština |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | مجله دانشگاه علوم پزشکی گرگان, Vol 18, Iss 3, Pp 86-91 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1562-4765 2008-4080 |
| Popis: | Background and Objective: The rise of antibiotic resistance particulary Methicillin resistance in pathogenic bacteria such as Staphylococcus aureus is found to be an emerging threat to human health especially in hospitals. Heavy metal nanoparticles such as Ag used for inhibition of this bacterium. This study was done to determine of minimum inhibitory concentration (MIC) Ag nanoparticle against Staphylococcus aureus which isolated in Gorgan, north of Iran and its relation with Methicillin resistance and source of bacteria. Methods: In this descriptive – analytical study, the MIC Ag nanoparticle in 183 isolates of Staphylococcus aureus by microdilution method was determined. 30 isolates, based on mecA gene was considered as MRSA. Samples were collected from patients, nose of healthy carriers and foods. Compare the MIC of isolates based on Methicillin resistance, source of the bacteria and resistance to other antibiotics were assessed. Results: Out of 183 samples MIC was varied from 1 to 16 µg/ml, and mean±std was 2.9±1.89 µg/ml. MIC mean of silver nanoparticles in isolated from foods were 2±0.7, isolared from healthy carriers were 4.1±2.4 and from patients were 3.4±2.1 µg/ml and were statically significant (P |
| Databáze: | Directory of Open Access Journals |
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